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The Secret Intelligence Service (SIS or MI6) is the British equivalent of the American CIA. Within the Chuck universe, it is commonly referred to by its unofficial previous title; "MI6" which referred to Military Intelligence Section 6, a title often used by the mass media, although files and documents provided by them feature the SIS logo.

The SIS is one of the oldest intelligence agencies in the world, having existed in one form or another since 1909, and it works in tandem with the domestic MI5 and GCHQ as part of the United Kingdom's "Joint Intelligence Committee ". The SIS Headquarters are in Vauxhall, London, on the banks of the River Thames, as seen in the 2012 James Bond film Skyfall.

In the Chuck Universe[]